Salt handling and hypertension
- 15 April 2004
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 113 (8) , 1075-1081
- https://doi.org/10.1172/jci200421560
Abstract
The kidney plays a central role in our ability to maintain appropriate sodium balance, which is critical to determination of blood pressure. In this review we outline current knowledge of renal salt handling at the molecular level, and, given that Westernized societies consume more salt than is required for normal physiology, we examine evidence that the lowering of salt intake can combat hypertension.Keywords
This publication has 67 references indexed in Scilit:
- Molecular Mechanisms of Human HypertensionCell, 2001
- A DASH of Data in the Salt DebateScience, 2000
- The (Political) Science of SaltScience, 1998
- Hypertension caused by a truncated epithelial sodium channel γ subunit: genetic heterogeneity of Liddle syndromeNature Genetics, 1995
- Liddle's syndrome: Heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channelCell, 1994
- Amiloride-sensitive epithelial Na+ channel is made of three homologous subunitsNature, 1994
- Liddle's Syndrome Revisited -- A Disorder of Sodium Reabsorption in the Distal TubuleNew England Journal of Medicine, 1994
- Abnormal renal function and autoregulation in essential hypertension.Hypertension, 1991
- Blood Pressure Control—Special Role of the Kidneys and Body FluidsScience, 1991
- Primary role of renal homografts in setting chronic blood pressure levels in rats.Circulation Research, 1975