A SENSITIVE COLORIMETRIC METHOD FOR THE DETERMINATION OF IMIPRAMINE HYDROCHLORIDE AND DESIPRAMINE HYDROCHLORIDE
- 1 August 1985
- journal article
- research article
- Published by Hindawi Limited in Journal of Clinical Pharmacy & Therapeutics
- Vol. 10 (4) , 373-377
- https://doi.org/10.1111/j.1365-2710.1985.tb00936.x
Abstract
A simple and rapid colorimetrc method for the determination of imipramine hydrochloride and desipramine hydrochloride in their tablet formulations and in biological fluids is presented. The method is based on the reaction of these drugs with 3-methyl-2-benzothiazolone hydrazone in the presence of ferric chloride, with direct measurement at 635 nm. Cyclohexane was used to extract these drugs from serum and urine, at basic pH, by a single manual extraction. The method can detect 0.5 .mu.g/ml of each drug. The main advantages of this method are its simplicity and high sensitivity.This publication has 10 references indexed in Scilit:
- Bestimmung von tricyclischen Antidepressiva und Neuroleptika aus Tabletten durch HPLCArchiv der Pharmazie, 1984
- Determination of cholesterol in seraClinica Chimica Acta; International Journal of Clinical Chemistry, 1983
- The analysis of tricyclic antidepressant drugs at therapeutic blood levels by reversed-phase high-performance liquid chromatography using pairing and organic counter-ionsJournal of Pharmaceutical and Biomedical Analysis, 1983
- Isocratic High-Performance Liquid Chromatographic Method for the Determination of Tricyclic Antidepressants and Metabolites in PlasmaJournal of Pharmaceutical Sciences, 1982
- Determination of 2-hydroxydesipramine by high-performance liquid chromatographyJournal of Chromatography B: Biomedical Sciences and Applications, 1981
- QUANTITATIVE MAPPING OF METABOLITES OF IMIPRAMINE AND DESIPRAMINE IN PLASMA SAMPLES BY GAS CHROMATOGRAPHIC-MASS SPECTROMETRY1981
- TRICYCLIC ANTI-DEPRESSANTS - A SIMPLIFIED APPROACH FOR THE ROUTINE CLINICAL MONITORING OF PARENT DRUG AND METABOLITES IN PLASMA USING HPLC1981
- Tricyclic Antidepressant Determination in Human Plasma by Gas-Liquid Chromatography Using Nitrogen-Phosphorous Detection: Application to Single-Dose Pharmacokinetic StudiesPharmacology, 1981
- High‐Performance Liquid Chromatographic Assay for Imipramine, Desipramine, and Their 2‐Hydroxylated MetabolitesJournal of Pharmaceutical Sciences, 1979
- Spot Test Detection and Colorimetric Determination of Aromatic Amines and Imino Heteroaromatic Compounds with 3-Methyl-2benzothiazolone HydrazoneAnalytical Chemistry, 1961