Renal glomerular function and long-term lithium therapy
- 1 March 1981
- journal article
- research article
- Published by American Psychiatric Association Publishing in American Journal of Psychiatry
- Vol. 138 (3) , 324-327
- https://doi.org/10.1176/ajp.138.3.324
Abstract
Recently published studies vary widely in the quantitative assessment of glomerular filtration rate (GFR) in Li-treated patients. Li-treated manic-depressive patients (99) were tested using several techniques to measure GFR. Ten of 86 patients who had no history of renal disease had mildly low creatinine clearance values. Significant correlations, which were not age-related, between the serum creatinine, Cockroft creatinine clearance and duration of Li therapy suggest a relationship between chronic Li therapy and declining GRF. Since serum creatinine alone was insensitive, the use of duplicate classical creatinine clearances confirmed by Cockroft values was recommended to monitor GFR during Li treatment.This publication has 1 reference indexed in Scilit:
- Age-Adjusted Standards for Creatinine ClearanceAnnals of Internal Medicine, 1976