Platelet Production

Publisher Website
Google Scholar
Abstract
PhysiologyMEGAKARYOCYTES arise from mononuclear precursors and undergo nuclear replication within a common cytoplasm as the initial identifiable phase of the life cycle of the cells. The number of nuclei doubles with each mitosis. In normal bone marrow about 65 per cent of the megakaryocytes contain eight diploid nuclei, 25 per cent have 16 nuclei, and 10 per cent have four nuclei.1 , 2 The cell then accumulates cytoplasm in direct proportion to the number of nuclei formed during nuclear proliferation — that is, the cell consists of four, eight or 16 "nuclear units."3 Cell maturation, which occurs mainly after nuclear proliferation, . . .

This publication has 7 references indexed in Scilit: