Neuron Number in the Entorhinal Cortex and CA1 in Preclinical Alzheimer Disease
Top Cited Papers
Open Access
- 1 September 2001
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 58 (9) , 1395-1402
- https://doi.org/10.1001/archneur.58.9.1395
Abstract
SEVERAL clinicopathologic studies of older adults with slight cognitive decline before death, just at the threshold for clinical detection, demonstrated large numbers of neurofibrillary tangles and amyloid plaques, sufficient for the diagnosis of Alzheimer disease (AD).1-8 Reasoning that these pathological lesions develop over time, the pathobiological processes that underlie AD must begin in a preclinical stage that precedes clinically detectable cognitive change, probably by years. This preclinical AD stage would be a critical target for therapeutic intervention.Keywords
This publication has 18 references indexed in Scilit:
- Neurofibrillary Tangles in Nondemented Elderly Subjects and Mild Alzheimer DiseaseArchives of Neurology, 1999
- Regional Distribution of Neuritic Plaques in the Nondemented Elderly and Subjects With Very Mild Alzheimer DiseaseArchives of Neurology, 1998
- A Prospective Study of Cognitive Function and Onset of Dementia in Cognitively Healthy EldersArchives of Neurology, 1998
- Frequency of Stages of Alzheimer-Related Lesions in Different Age CategoriesNeurobiology of Aging, 1997
- Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s DiseaseNeurobiology of Aging, 1997
- Neuropathology in controls and demented subjects from the Baltimore longitudinal study of agingNeurobiology of Aging, 1996
- The Clinical Dementia Rating (CDR)Neurology, 1993
- Regionally specific loss of neurons in the aging human hippocampusNeurobiology of Aging, 1993
- Neuropathological stageing of Alzheimer-related changesActa Neuropathologica, 1991
- The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosisAPMIS, 1988