Sulpiride anxiogenic-like effect inhibition by a D1 dopamine receptor antagonist
- 1 October 1992
- journal article
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 3 (10) , 941-942
- https://doi.org/10.1097/00001756-199210000-00031
Abstract
The increased latency to explore a white compartment from a black one into which a mouse has been introduced, appears to be correlated with its anxiety level. In this test, the D2 specific dopamine receptor antagonist (+/-) sulpiride dose dependently (5-40) mg kg-1 i.p.) increased this latency. This effect was suppressed by the D1 specific dopamine receptor antagonist SCH 23390 (25 micrograms kg-1 s.c.) which intrinsically displayed an apparent anxiolytic effect.Keywords
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