Availability of PSC833, a substrate and inhibitor of P-glycoproteins, in various concentrations of serum
Open Access
- 5 August 1998
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 90 (15) , 1161-1166
- https://doi.org/10.1093/jnci/90.15.1161
Abstract
Mammalian cells can become resistant to several chemotherapeutic drugs after selection with a single drug in vivo or in vitro . This multidrug resistance can be caused by P-glycoproteins (P-gps) ( 1 , 2 ) encoded by the human multiple drug resistance 1 (MDR1) gene and the murine mdr1a and mdr1b genes (also known as mdr3 and mdr1, respectively). P-gps are cell membrane proteins that render cells resistant to cytotoxic drugs by actively extruding drugs from the cytoplasm into the extracellular space, resulting in a decreased drug concentration inside the cell ( 3 – 6 ).Keywords
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