SUPPRESSION BY IGA OF IGG-MEDIATED PHAGOCYTOSIS BY HUMAN POLYMORPHONUCLEAR LEUKOCYTES

  • 1 January 1978
    • journal article
    • research article
    • Vol. 34  (3) , 423-428
Abstract
Ig[immunoglobulin]A from normal human serum, a myeloma IgA and human colostral IgA inhibited the IgG-dependent phagocytosis of Candida albicans (CA) blastospores by polymorphonuclear leukocytes (PMN) from normal human subjects. The inhibition was dependent on the Fc portion of IgA, was enhanced by heat treatment (56 C for 20 min) and depended on binding to the PMN, but not to the opsonized particle. Binding of CA to the PMN IgG Fc receptor was inhibited; the binding to the PMN C3b [b fragment of complement component 3] receptor was unaffected.