Penetration and Distribution of Topically Applied Malathion in the House Fly12

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Abstract
Penetration and distribution in Musca domestica L. of topically applied malathion was studied using a high and low dose of 14C-malathion. With the low dose a longer period was required for the internal distribution. Penetration was highest at the site of application. The malathion moved through the cuticle and into the hemolymph within 15 seconds. From the hemolymph it concentrated in muscle tissue, midgut, and salivary glands of the thorax, In susceptible-strain flies higher concentrations of material were found in muscle tissue than in resistant-strain flies. Later, activity was found in the head (brain) and abdominal tissue, the malathion being distributed by the hemolymph.

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