Mutant with heat-sensitive capacity for phagocytosis in tetrahymena: isolation and genetic characterization

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Abstract
SUMMARY: A mutant ofTetrahymenawith heat-sensitive phagocytosis was obtained using a tantalum-particle enrichment procedure. The mutant phenotype is most likely determined by a somatic (macronuclear) mutation(s). The inability of the mutant to sustain cell division and to phagocytize at 37 °C are most likely determined by the same mutation. The phenotype of the mutant is stably inherited under vegetative propagation at 30 °C. At 37 °C, the mutation affects the development of the oral apparatus, the phagocytotic organelle. This mutant has proven useful for the study of cellular functions related to phagocytosis.
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