An Individual with a High Prevalence of aTat-Defective Provirus in Peripheral Blood
- 1 December 1993
- journal article
- research article
- Published by Mary Ann Liebert Inc in AIDS Research and Human Retroviruses
- Vol. 9 (12) , 1265-1268
- https://doi.org/10.1089/aid.1993.9.1265
Abstract
The first exon of tat was sequenced from 23 provirus genomes randomly amplified directly from an HIV-1-infected individual's peripheral blood. Twelve of the 23 sequences constituted a distinct subset of the quasispecies detected. This subset had in common two inactivating mutations in the tat gene. In addition, two of these defective genomes each had a unique mutation. This is the second instance of a defective early gene being present in a high percentage of the proviruses present in the PBMCs of an HIV-1-infected individual, (the first reported by Martins LP etal.: J Virol 1991;65:4502–4507), and suggests that genomes defective in an early gene can participate in the infectious spread of HIV-1 in vivo.Keywords
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