Cardiovascular Hemodynamics

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Abstract
Iodinated I 131 serum albumin aggregated, when injected intravenously into seated patients, affords an accurate measurement of certain hemodynamic indices. In patients with mitral stenosis, the ratio of distribution of this drug in the upper and middle portions of the lungs correlates well with pulmonary arterial and left atrial pressures and inversely with cardiac output. The presence of idiopathic pulmonary hypertension, but not its severity, can be determined, since the flow distribution pattern becomes relatively uniform despite a wide pressure range. The method has considerable advantage over the radioactive gas techniques with oxygen 15, krypton 85, and xenon 133, since the radioactive serum albumin is more easily handled and has only arterial distribution without an alveolar gas phase. Caution should be exercised in relying completely upon the results of the lung scans and ratios where emphysema, congestive heart failure, and pulmonary emboli concomitantly exist.

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