Physical-Chemical Factors Affecting the Preparation of a Coarse Solid Dispersion by Crystallization of Indowhacin from a Metastable Solid Solution

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Abstract
The extent of crystallization of indomethacin as a coarse solid dispersion from a metastable solid solution was determined by three methods. An apparent critical degree of super saturation (C35) was indicated by the intersection of a bilinear plot obtained from growth rate constants measured on the surface. The crystal growth rate on the surface was found to be dependent on the degree of super saturation, storage temperature, and presence of a nucleating agent. A rank order correlation was obtained between a visual and a dissolution method for determining the extent of crystallization. The effect of adding a nucleating agent (sodium chloride) on the extent of crystallization was determined with a color difference meter.

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