Maternal and Foetal Drug Levels After Epicutaneous Application of a Local Anaesthetic Formulation Containing Ketocaine For Possible Use as Pain Relief in Labour

Publisher Website
Google Scholar
Abstract
A local anesthetic formulation (A 2358) containing ketocaine, a local anesthetic drug, was applied epicutaneously to the low back in humans. Two compresses soaked with A 2358 were applied for 1 h in 26 normal labors for relieving pain from the low back. The maternal blood ketocaine levels remained low, compared to higher systemic levels reported in other studies. Maternal heart rate and blood pressure were stable during the application time. The mean umbilical vein/maternal vein and umbilical artery/maternal vein concentration ratios were 0.20 .+-. 0.10 and 0.21 .+-. 0.09. The fetal heart rate findings and the conditions of the neonates were satisfactory, suggesting the fetal safety of this analgesic method.

This publication has 4 references indexed in Scilit: