The biosynthesis of the sesquiterpenoid tricothecane antibiotics

1 January 1970

journal article
research article
Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society D: Chemical Communications

No. 8,p. 511a
https://doi.org/10.1039/c2970000511a

Abstract

The location of the 4(R)-[4-³H]mevalonoid hydrogen atoms at C-2 and C-10, and the incorporation of tritium from 1- and 2-³H-farnesol pyrosphosphate, suggest that a 6,7-trans-farnesol pyrophosphat acts as a precursor of the Tricothecane antibiotics.

Keywords

BIOSYNTHESIS
SESQUITERPENOID TRICOTHECANE
ANTIBIOTICS
3H FARNESOL
HYDROGEN ATOMS
FARNESOL PYROPHOSPHAT
TRANS FARNESOL
PYROPHOSPHAT ACTS