Bacterial endotoxin (lipopolysaccharide) as a cause of erythema multiforme
- 4 January 1980
- journal article
- research article
- Published by American Medical Association (AMA) in JAMA
- Vol. 243 (1) , 58-60
- https://doi.org/10.1001/jama.243.1.58
Abstract
The classic iris lesion in a patient with erythema multiforme bullosum were reproduced grossly and microscopically by the intradermal injection of a variety of heat-killed, gram-negative bacteria and their common endotoxin, lipopolysaccharide [LPS] W. In vitro exposure of the patient''s blood to these antigens induced specific fibrin microclots characteristic of a hypersensitivity state. Some cases of erythema multiforme associated with a variety of respiratory, gastrointestinal or urinary tract infections may represent a single specific delayed sensitivity reaction to the bacterial LPS.This publication has 4 references indexed in Scilit:
- Erythema Multiforme: Immune Complex Vasculitis of the Superficial Cutaneous MicrovasculatureJournal of Investigative Dermatology, 1978
- Oriented fibrin crystallization: a phenomenon of hypersensitivity to bacteria in psoriasis, vasculitis and other dermatosesBritish Journal of Dermatology, 1977
- Erythema multiforme: Report of two cases and speculation on immune mechanisms involved in the pathogenesisClinical Immunology and Immunopathology, 1977
- Herpes Simplex Virus as a Cause Of Erythema MultiformeJAMA, 1967