ALLOIMMUNE IGG BINDS AND MODULATES CARDIAC BETA-ADRENOCEPTOR ACTIVITY

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  • 1 January 1984
    • journal article
    • research article
    • Vol. 58  (1) , 223-228
Abstract
Purified IgG from murine alloimmune sera directed against class I products from the major histocompatibility complex of the mouse could bind to the .beta.-adrenoceptors and stimulate contractile activity of myocardium. Immune IgG inhibited the binding of (-) 3H-DHA to .beta.-adrenoceptors of mouse myocardial membranes behaving as a competitive inhibitor. Moreover, immune IgG induced positive inotropic and chronotropic effects on isolated mouse atria. These affects could be blocked by .beta.-adrenoceptors antagonists. Immune IgG directed against specific alloantigens are apparently able to recognize the .beta.-adrenoceptors and mimic the stimulation of the .beta.-adrenoceptor agonist.