Effect of Anti-β2-Microglobulin on Antigen and Allogeneic Lymphocyte-Induced Proliferation of Human Lymphocytes

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Abstract
The effect of anti-β2-microglobulin (β2m) on the mixed lymphocyte reaction (MLR), and an antigen-induced proliferative response was studied. Anti-β2m IgG and Fab′ fragments completely inhibited the MLR. Preincubation of stimulator or responder cells with anti-β2m suggested that the major effect of anti-β2m may be on the responder cell population. A clear-cut effect on responder cells was demonstrated by showing that anti-β2m completely inhibited a MLR in which the stimulator population was a β2m negative lymphoblastoid cell line. Anti-β2m also inhibited PPD-induced proliferation of sensitized lymphocytes. The kinetics of this inhibition indicated that anti-β2m added within the first 18 hr of stimulation was effective in inhibiting the proliferative response. These data are discussed in light of the hypothesis that β2m may be a subunit of an antigen receptor on T cells.

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