Effects of Cholesterol and Other Substances on Essential Fatty Acid Deficiencies

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Abstract
Cholesterol and sodium glycocholate accelerated EFA-deficiency symptoms using diets containing 3% of saturated fat; this effect was not observed on fat-free diets. Both substances retarded growth. Cholic acid did not accelerate EFA-deficiency symptoms, but retarded growth and body-fat deposition and produced diarrhea. The diarrhea was alleviated by increased supplements of a rice bran concentrate but growth was not improved. Growth was improved by dietary cholesterol and fat. When cholesterol was fed with either sodium glycocholate or cholic acid, the lipid content of the liver increased several fold. However, sodium glycocholate was the more effective of the two supplements, with cholesterol, to increase liver lipids and accelerate EFA-deficiency symptoms.