SUSTAINED-RELEASE OF BCNU FOR THE TREATMENT OF INTRA-OCULAR MALIGNANCIES IN ANIMAL-MODELS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 18  (10) , 1061-1067
Abstract
Sustained release of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) via an episcleral implanted silicone device was used to treat Brown-Pearce epithelioma in the anterior chamber of rabbit eyes. One group of test eyes received BCNU dissolved in sesame oil; a 2nd group received BCNU in pure ethanol. Control eyes received only the diluent, sesame oil or pure ethanol. The effectiveness of the various dosages and diluents was compared by clinical observation, by weight of the enucleated eyes, and by histopathologic examination. Sustained release of BCNU via an episcleral implanted silicone device delayed for growth of Brown-Pearce epithelioma in rabbit eyes of both test groups. The most effective action resulted from administration of BCNU in pure ethanol.

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