Hemodynamic effects of intravenous lecithin-based perfluorocarbon emulsions in dogs

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Abstract
We evaluated and compared the acute hemodynamic effects of perfluoroocrylbromide-100% (PFOB), a fluorocarbon emulsified in lecithin without pluronic-F68 (F68), to those of a standard iodinated contrast agent. renografin-76% (R76), and Fluosol-DA 20% (Fluosol), a fluorocarbon emulsified in part by F68. Five open chest dogs were instrumented to evaluate hemodynamic changes after iv injection of PFOB (1 ml ± g/kg) and R76(l ml 0.37 g of iodine/kg). Fluosol (1 ml ± 0.2 g/kg) was given to two of the five dogs at the end of their study. Fluosol caused transient hemodynamic collapse in both dogs. R76 caused the known transient effect of hypotension (-15.4 ± 3.3%) followed by hypertension (6.5 ± 2.7%) and an increase in aortic flow (29.3 ± 3.9% at 30 sec). PFOB caused minimal, clinically insignificant decrease in aortic flow (4 ± 1% at 10 sec).

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