FACTORS AFFECTING THE THYROID GLAND UPTAKE OF I131OF THERANA CATESBEIANATADPOLE1

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Abstract
Various factors affecting thyroid gland uptakes of I131 of the tadpole have been studied. The species of Rana catesbeiana was used since they were widely available the year around in the larval form. All observations, except for one study, were made on non-metamorphosing tadpoles fasted 7 to 14 days. Temperature had a marked effect on the uptake and must be critically controlled to compare responses of these poikilothermic animals. The responses varied during the months of the year being greatest in April and least in October, November and December. When single injections of TSH and I131 were given the greatest difference in the mean uptake between the stimulated and unstimulated tadpoles was observed when TSH was given 68 hours and I131 24 hours before sacrifice. Twenty-five [mu]g. triiodothyronine placed in the tadpole water bath of approximately 1200 ml. suppressed the 24 hour uptake by 50%. This effect occurred within 24 hours and lasted at least 96 hours. The response to TSH was not decreased by the triiodothyronine.

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