Aberrant DNA methylation of the p16INK4a gene in plasma DNA of breast cancer patients
Open Access
- 28 May 1999
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 80 (8) , 1262-1264
- https://doi.org/10.1038/sj.bjc.6690495
Abstract
Hypermethylation of exon 1 of p16INK4a was examined in tumour and plasma DNA of a series of breast cancer patients. De novo methylation was observed in the tumours of eight patients (23%), and in plasma DNA in five (14%) of these eight patients. Our data show that de novo methylation of exon 1 of p16INK4a can be demonstrated in plasma DNA of breast cancer patients, a fact that provides additional evidence of the tumour-related origin of free plasma DNA in cancer patients.Keywords
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