Randomized Double-blind Study Comparing the Efficacy of Gabapentin With Amitriptyline on Diabetic Peripheral Neuropathy Pain
Open Access
- 13 September 1999
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 159 (16) , 1931-1937
- https://doi.org/10.1001/archinte.159.16.1931
Abstract
DIABETIC PERIPHERAL neuropathy (DPN) is one of the most common symptomatic, long-term complications in patients with both type 1 and type 2 diabetes mellitus.1 At initial diagnosis, 7.5% of patients will already experience DPN pain, and approximately 45% will be afflicted with this complication after 25 years.2 At this time, however, the exact cause of DPN is not well understood.3,4This publication has 23 references indexed in Scilit:
- Use of Gabapentin in Pain ManagementAnnals of Pharmacotherapy, 1997
- Gabapentin (neurontin) and S‐(+)‐3‐isobutylgaba represent a novel class of selective antihyperalgesic agentsBritish Journal of Pharmacology, 1997
- Reflex sympathetic dystrophy treated with gabapentinArchives of Physical Medicine and Rehabilitation, 1997
- Mexiletine in the Symptomatic Treatment of Diabetic Peripheral NeuropathyAnnals of Pharmacotherapy, 1997
- Anticonvulsant drugs for management of pain: a systematic reviewBMJ, 1995
- Investigation of peripheral neuropathy.Journal of Neurology, Neurosurgery & Psychiatry, 1995
- Mexiletine in the Treatment of Diabetic NeuropathyDiabetes Care, 1992
- New Understanding and Treatment of Diabetic NeuropathyNew England Journal of Medicine, 1992
- Effects of Desipramine, Amitriptyline, and Fluoxetine on Pain in Diabetic NeuropathyNew England Journal of Medicine, 1992
- Amitriptyline relieves diabetic neuropathy pain in patients with normal or depressed moodNeurology, 1987