Effect of Amiodarone on Blood Lipids
- 1 January 1986
- journal article
- research article
- Published by S. Karger AG in Cardiology
- Vol. 73 (3) , 147-150
- https://doi.org/10.1159/000173998
Abstract
Amiodarone is a potent antiarrhythmic drug with a prolonged half life. The administration of amiodarone for 6 weeks in rabbits caused a significant elevation of serum lipids. We measured serum lipoproteins in 24 patients before, 30 and 90 days after treatment with amiodarone. Serum triglycerides decreased for all patients from 140.1 .+-. 11.6 to 122.7 .+-. 10.2 (p < 0.05) whilst total cholesterol decreased from 211.4 .+-. 19.5 to 194.4 .+-. 13.3 (p = 0.08) in female patients only. There was no change in high density lipoprotein concentrations. These data are in contrast to those found in rabbits and are probably due to the smaller doses of amiodarone used on our patients.This publication has 4 references indexed in Scilit:
- The Lipid Research Clinics Coronary Primary Prevention Trial ResultsJAMA, 1984
- Clinical pharmacokinetics and efficacy of amiodarone for refractory tachyarrhythmias.Circulation, 1983
- Elevation of serum lipids after chronic administration of amiodarone in rabbitsAtherosclerosis, 1982
- Cholesterol determination in high-density lipoproteins separated by three different methods.Clinical Chemistry, 1977