Effects of chlorpromazine on primary-process thought manifestations.

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Abstract
The object of the present study was to determine the effect of chlorpromazine on primary-process thinking. Subjects were 40 institutionalized schizophrenics who were randomly assigned to either a drug or placebo group. Research data were obtained from pre- and postdrug Rorschach protocols, which were scored using Holt''s (1959) method. The most outstanding finding was the striking improvement in mean defense effectiveness. Drug patients proved to be more capable of handling primary-process elements; the more so, the more they were rated as clinically improved. The insignificant changes in the sum of Level 1 primary process and mean defense demand suggest that the degree of thought pathology itself is not directly affected by drug treatment.

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