Glucose Metabolism in Normal Human Thyroid Tissue in vitro*

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Abstract
Glucose and energy metabolism have been studied in human thyroid tissue in vitro. The pattern of metabolism was found to be similar to the pattern previously described in dog thyroid tissue: very active glycolysis but poorly active pentose phosphate pathway and predominance of mitochondrial versus glycolytic ATP supply. TSH (at low concentrations t 0.1 mU/ml) decreased the oxidation of glucose carbon 1 but enhanced it at high concentrations. Dibutyryl cyclic 3′,5′‐AMP mimicked the effect of low TSH concentrations. At all concentrations TSH enhanced iodide binding to proteins. TSH also enhanced glucose uptake and lactate formation. The action of various transmitters (carbamyl‐choline, epinephrine, prostaglandin E1, serotonin and histamine) on glucose oxidation and iodide binding to proteins was studied. The action of these transmitters demonstrated wide species variation.