IMMUNE-COMPLEX GLOMERULONEPHRITIS MEDIATED BY THYROID ANTIGENS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 102  (10) , 530-533
Abstract
Hypothyroidism, microscopic hematuria and proteinuria developed in an 11 yr old girl. A renal biopsy specimen showed increased mesangial cells and matrix with focal glomerular basement membrane thickening. After 3 yr, a pronounced increase in proteinuria was detected. Elevated levels of antibody to thyroid microsomal antigen and thyroglobulin were found in the serum. A renal biopsy specimen showed a pronounced increase in mesangial cells and matrix with generalized glomerular basement membrane thickening. EM studies demonstrated granular deposits in the capillary walls and mesangium. Immunofluorescent studies revealed granular deposits of Ig[immunoglobulin]G, IgM and C3 [3rd complement component], primarily on the glomerular basement membrane. By indirect immunofluorescence, granular glomerular basement membrane and mesangial staining were detected with antibody specific for thyroglobulin and thyroid microsomal antigen. These observations suggest development of immune complex glomerulonephritis mediated by thyroid antigens.

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