Effect of Phenylalanine Metabolites on Urinary Excretion of Indole-3-acetic Acid and 5-Hydroxyindole-3-acetic Acid in Man.
- 1 February 1960
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 103 (2) , 407-410
- https://doi.org/10.3181/00379727-103-25538
Abstract
The oral administration of phenylpyruvic acid, phenylacetic acid, and o-hydroxyphenylacetic acid to human subjects produced an increase in the urinary excretion of indoleacetic acid. o-Hydroxyphenylacetic acid produced the greatest increase. A smaller increase in the excretion of 5-hydroxyindoleacetic acid followed the administration of phenylpyruvic acid or phenylacetic acid. The relation of these findings to the inhibition of tryptophan decarboxylase and 5-hydroxytryptophan decarboxylase is discussed.Keywords
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