A Pulse-radiolysis Study of the Reaction of Hydrated Electrons with N′-formylkynurenine and Related Compounds: Electron-transfer Reactions with Nucleic Acid Components

Publisher Website
Google Scholar
Abstract
The reactivity of N''-formylkynurenine (FK) derivatives to eaq [hydrated electron] was investigated. The reduced transient species were characterized (.lambda.max .apprx. 340, 440 nm, .epsilon..lambda.max .apprx. 3000-1000 M-1 cm-1, pKa .apprx. 7.8). Owing to the strong FK electron affinity, electron-transfer reactions occur from purine (except guanine) and pyrimidine electron adducts to FK (k .apprx. 2-7 .times. 109 M-1 s-1). As some FK derivatives bind to DNA (or polynucleotides) the protective effect of complexation on FK-DNA (or polynucleotides) adduct formation has been investigated.

This publication has 13 references indexed in Scilit: