One-Step Synthesis of Acetylenes from Ketones
- 1 January 1974
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 4 (1) , 25-27
- https://doi.org/10.1080/00397917408062050
Abstract
The classical route to acetylenes from ketones involves the formation of gem-dichlorides or vinyl chlorides followed by elimination of hydrogen chloride with alkali hydroxides or amides.1 The use of these latter reagents is evidently incompatible with compounds having other functional groups which are sensitive to strong bases. A need to preserve a carboxylic ester present in the same molecule in which a methyl ketone is to be transformed into the ethynyl moiety led us to investigate the modification of the dehydrochlorination process, and we wish to communicate our preliminary findings.Keywords
This publication has 1 reference indexed in Scilit:
- The reactions of triphenylphosphine in carbon tetrachloride with enolisable ketonesJournal of the Chemical Society, Chemical Communications, 1972