Analysis of a Simple Prototypal Muscle Model Near to and Far from Equilibrium
- 1 May 1974
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 71 (5) , 1982-1986
- https://doi.org/10.1073/pnas.71.5.1982
Abstract
Accurate calculations of force generated and of ATP flux, in steady isotonic contractions, are made on a simple, two-state muscle model of the sliding filament type. The objective is to illustrate the proper formulation and use of a complete and self-consistent molecular model of muscle. Otherwise, the model is not meant to be realistic. Calculations were made near equilibrium, including linear and quadratic terms in a power series expansion, and arbitrarily far from equilibrium by direct numerical solution of the appropriate differential equation in the probability of cross-bridge attachment. The results obtained from the two different methods agree where they overlap near equilibrium. The efficiency of free energy conversion is emphasized, and the relation to linear irreversible thermodynamics is pointed out.Keywords
This publication has 2 references indexed in Scilit:
- On the sliding-filament model of muscular contraction, IV. Calculation of force-velocity curves.Proceedings of the National Academy of Sciences, 1968
- On the sliding-filament model of muscular contraction, II.Proceedings of the National Academy of Sciences, 1968