Effects of prostaglandin I2 and E2 on renal hemodynamics and function and renin release.

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Abstract
The effects of PG[prostaglandin]I2 and PGE2, given in the same doses, were compared as to renal hemodynamics and functions and renin release. The same experimental conditions were used for both compounds and experiments were carried out in pentobarbital anesthetized dogs. Adrenergic influences were excluded by renal denervation. Given intrarenally at doses of 0.1 and 1 .mu.g/min, PGE2 caused significant increase in RBF [renal blood flow], UF [urine flow] and UNa V [urinary Na excretion rate], but had no effect on BP [blood pressure] and GFR [glomerular filtration rate]. Intrarenal infusion of PGI2 at a rate of 1 .mu.g/min resulted in a significant increase of RBF and in a marked fall of BP, but only little change in GFR, UF and UNaV. With a dose of 0.1 .mu.g/min, the parameters remained the same. I.v. infusion of PGI2 (1 .mu.g/min) caused a significant fall in BP with no change in the other parameters. PGI2 and PGE2 had a similar effect on intrarenal hemodynamics, i.e., caused a progressively greater proportional vasodilation from superficial to deep cortex. Given intrarenally at 1 .mu.g/min, PGI2 and PGE2 increased renin release. At 0.1 and 1 .mu.g/min i.v., renin secretion was not influenced. The effect of PGI2 on systemic blood pressure was more potent than that of PGE2 with regard to renal vasodilating action and tubular effects, PGE2 was the more potent. PGI2 and PGE2 evidently stimulate renin secretion through a direct action on the juxtaglomerular cells.