NEPHROTOXIC EFFECTS OF LONG-TERM CARBON-TETRACHLORIDE ADMINISTRATION IN RATS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 104  (2) , 94-99
Abstract
Rats were given bi-weekly injections of CCl4 for up to 34 wk to investigate the long-term effects on the kidney. Nephrotoxicity was manifest by an increase in urinary protein and albumin excretion as compared with the values in control rats receiving corn oil. Differences in urinary protein excretion were significantly greater in female rats receiving CCl4 for 13 wk. Unilateral nephrectomy accentuated proteinuria in female rats. Rats receiving CCl4 also had more glomerular sclerosis and dilated and cast-filled tubules than did control rats. Immunofluorescence revealed immunoglobulins without C3 in glomeruli of both control and experimental animals, but more fibrinogen in CCl4-treated rats. Long-term exposure to CCL4 can produce glomerular disease in rats and could possibly be glomerulotoxic in man.