The CGD Leukocyte — A Model of Impaired Phagocytic Function

Publisher Website
Google Scholar
Abstract
Phagocytosis by leukocytes, serum immunoglobulins and lymphocyte function are vital host defenses against invading micro-organisms. Since Metchnikoff's discoveries in 1883, a clearer understanding of the morphologic and metabolic changes that occur during phagocytosis of bacteria and fungi by peripheral blood leukocytes has developed. Serum factors enhance this process, and specific defects of such factors have recently been implicated as a cause for increased susceptibility to infection.1 The dynamic process of particle ingestion by phagocytes involves both expenditure of energy and renewal of cell membranes. Karnovsky2 and his co-workers have established that the leukocyte derives its energy from glycolysis and that . . .