Prenatal diagnosis of severe congenital malformations associated with elevated amniotic fluid alpha-feto protein

Abstract
Two cases of severely malformed infants with abnormal fetal images on B-scan sonography and markedly elevated amniotic fluid AFP [.alpha.-fetoprotein] are presented. There was no evidence of neural tube anomalies. The importance of amniocentesis and AFP in pregnancies with an abnormal fetal image on B-scan sonography is emphasized, taking into consideration that most pregnancies with elevated fluid AFP have serious fetal anomalies.