Glucose Uptake by Isolated Normal and Diabetic Rat Lenses

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Abstract
The uptake of glucose by isolated lenses from normal and diabetic rats has been measured and found to average 1.1 and 0.5 mg of glucose/gm of lens/hr., respectively. The uptake is not affected by fasting the rats or by the addition of insulin to the incubation medium. The injection of insulin 2 hours before killing increases the uptake of normal lenses to 1.4 mg of glucose/gm of lens/hr. The same result is obtained if the blood sugar level of the insulin injected animal is maintained by intraperitoneal administration of glucose.

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