Dependence of Apparent Blood Lead Half-Life on the Length of Previous Lead Exposure in Humans

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Abstract
Dependence of Apparent Blood Lead Half-Life on the Length of Previous Lead Exposure in Humans. O'FIaherty, E.J., Hammond, P.B. and Lerner, S.I. (1982). Fundam. Appl. Toxicol. 2:49–54. The expected relationship between the apparent half-life of blood lead (PbB) and the length of previous exposure is compared with the observed relationship in a group of workers on strike from a primary smelter where they had been employed for from a few months to ten years. Within this group, the apparent PbB half-life was positively correlated both with pre-strike PbB and with length of exposure to lead. It is likely that the dependence of apparent half-life on pre-strike PbB is primarily a reflection of interindividual differences in lead kinetics in these men. The direct dependence of apparent half-life on duration of lead exposure is consistent with published data from former lead workers and from human subjects experimentally exposed to lead.

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