Cofilin, an intracellular marker for HIV‐associated CD4 T‐cell motility dysregulation, shed light on the mechanisms of incomplete immune reconstitution in the patients with HIV
Top Cited Papers
- 9 September 2019
- journal article
- editorial
- Published by Wiley in Journal of Medical Virology
- Vol. 92 (1) , 1-3
- https://doi.org/10.1002/jmv.25577
Abstract
Highlights: People living with HIV do not achieve an optional immune reconstitution despite the sustained virologic suppression. Circulating CD4 T cells fail to replenish their lymphoid tissue counterparts in people living with HIV. Irrespective of ART, coffin hyperactivation and impaired T cell mobility persist in people living with HIV. Cofilin may represent a novel therapeutic target to restore T cell mobility in people living with HIV.Funding Information
- Bill and Melinda Gates Foundation (OPP1035237)
- National Institute of Allergy and Infectious Diseases (R01AI117835, R21AI104268)
This publication has 10 references indexed in Scilit:
- Cofilin hyperactivation in HIV infection and targeting the cofilin pathway using an anti-α 4 β 7 integrin antibodyScience Advances, 2019
- Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin PolymerizationThe Journal of Immunology, 2017
- Primary Human Leukocyte Subsets Differentially Express Vaccinia Virus Receptors Enriched in Lipid RaftsJournal of Virology, 2013
- Immune Activation and Collateral Damage in AIDS PathogenesisFrontiers in Immunology, 2013
- Follicular helper T cells serve as the major CD4 T cell compartment for HIV-1 infection, replication, and productionThe Journal of Experimental Medicine, 2012
- Expansion of HIV-specific T follicular helper cells in chronic HIV infectionJournal of Clinical Investigation, 2012
- The role of secondary lymphatic tissue in immune deficiency of HIV infectionAIDS, 2008
- HIV Envelope-CXCR4 Signaling Activates Cofilin to Overcome Cortical Actin Restriction in Resting CD4 T CellsCell, 2008
- Cofilin activation in peripheral CD4 T cells of HIV-1 infected patients: a pilot studyRetrovirology, 2008
- Actin cytoskeletal dynamics in T lymphocyte activation and migrationJournal of Leukocyte Biology, 2003