Topical Budesonide Treatment Reduces Endothelial Expression of Intercellular Adhesion Molecules (Vascular Cell Adhesion Molecule-1 and P-selectin) and Eosinophil Infiltration in Nasal Polyps

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Abstract
Infiltration of eosinophil granulocytes and endothelial expression of vascular cell adhesion molecule-1 (VCAM-1) and P-selectin was investigated in biopsies of polyps and inferior turbinates from 16 patients with nasal polyps, by the use of immunohistochemical staining and stereological quantification before, during and after topical treatment with budesonide (Rhinocort® Turbuhaler®). Before glucocorticoid treatment a higher density of eosinophil profiles (ppppppp<0.02) in polyps. Eosinophil counts and VCAM-1 expression returned to pre-treatment levels 8 weeks after discontinuation of budesonide treatment. The observed reduction in endothelial expression of cellular adhesion molecules may interfere with cellular recruitment in nasal polyps and thus contribute to the known anti-inflammatory effect of glucocorticoid in nasal polyposis.