Antigenic Analysis of the Hemagglutinating Subunits of the Animal Influenza Virus Strains A/Equine-2/Milford/2/63, A/Equine-2/Miami/I/63 and A/Duck/England/62

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Abstract
Summary: The antigenic composition of the hemagglutinating subunits produced by ether treatment of the animal influenza virus strains A/Equine-2/Milford/2/63, A/Equine-2/Miami/1/63 and A/Duck/England/62 was analyzed. Both Equine-2 strains were found to contain A/1/PR 301 and A/2/AA/23/57 components as minor antigens, and the Milford strain, in addition, contained an A/Swine component. The relative concentration of these antigenic components was determined and it was found that about half the hemagglutinating activity of ether-treated Equine-2 viruses is represented by doubly-antigenic hemagglutinins that carry the major antigen in combination with one of the minor antigens. The hemagglutinating subunits of the strain A/Duck/England/62 were also found to be antigenically inhomogenous. However, the identification of minor antigens was not achieved. The antibody response to vaccination with intact and ether-treated human influenza viruses was tested comparatively. The strains A/Swine, A/1/PR 301 and A/2/23/57 were found to contain an A/Equine-2/Milford/2/63 component. In contrast, no evidence for the presence of A/Equine-2/Miami/1/63 or A/Duck/England/62 components in human strains was obtained. The patterns of cross-reaction of intact and ether-treated animal viruses were found to reflect primarily their major antigenic components and were not measurably influenced by the minor antigenic components as identified in ether-treated viruses.

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