Integrative Mechanisms in the Nervous System

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Abstract
It has been supposed that all-or-none nerve impulses are the only important feature of nerve function and most properties of the central nervous system (c.n. s.) have been ascribed to the elaborate organization of the nerve centers. Recent experiments show that nerve cells generate graded response in addition to all-or-none impulses and it appears that graded nerve activity can account for some simple manifestations of integration. Interpretation of complex c.n.s. functions should therefore take into account graded activity together with impulse activity and structural organization.