Regression de métastases de mélanome après thérapeutique immunologique

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Abstract
In one patient, the appearance of superficial skin metastases of melanoma was not modified by scarification with vaccinia vaccine. Regression was observed after topical application of 2,4-dinitrochloro-benzene which resulted in complete clearing of the tegument which had persisted for over 2 years. Histological examination of some of the regressing lesions revealed infiltration by mononuclear cells and eosinophils as well as the disappearance of the neoplastic melanocytes.

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