Both R5 and X4 Human Immunodeficiency Virus Type 1 Variants Persist during Prolonged Therapy with Five Antiretroviral Drugs
- 15 March 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (6) , 3054-3058
- https://doi.org/10.1128/jvi.76.6.3054-3058.2002
Abstract
A viral reservoir of human immunodeficiency virus type 1 (HIV-1)-infected, resting CD4+T cells persists despite suppression of plasma viremia by combination antiretroviral therapy. In a longitudinal analysis of three patients treated with a five-drug regimen, both R5 and X4 HIV-1 variants persisted in the cellular reservoir for up to 3 years.Keywords
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