Immune Thrombocytopenic Purpura — The Changing Therapeutic Landscape

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Abstract
Immune thrombocytopenic purpura (ITP) in adults is usually a chronic disease in which a low platelet count often causes mucocutaneous bleeding. ITP is a diagnosis of exclusion. Pseudothrombocytopenia and such disorders as drug-induced thrombocytopenia, microangiopathic thrombocytopenia, bone marrow failure, and congenital thrombocytopenia must be ruled out. The disorder can be primary (idiopathic) or secondary. Secondary ITP is associated with systemic lupus erythematosus, chronic lymphocytic leukemia, lymphoma, HIV infection or full-blown AIDS, hepatitis C infection, and a variety of other disorders.Multiple mechanisms cause the thrombocytopenia in ITP, so the disorder is likely to be heterogeneous.1 Over 50 years ago, Harrington . . .

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