Effects of indapamide on excitation-contraction coupling in smooth muscle of the mammalian portal vein

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Abstract
Action potentials and trans-membrane currents were measured in smooth muscle bundles of the rat or rabbit portal vein by means of a double sucrose gap technique. A photo-electric device was used for simultaneous recording of the muscle contraction. The electrophysiological and mechanical responses of the preparation to electrical stimulation were studied in the presence of indapamide (10-5 to 10-3 g/ml). The effect of indapamide on responses to angiotensin and noradrenaline were also investigated. Indapamide decreased the amplitude of the action potential, the inward calcium current and the phasic contraction. The electrophysiological and mechanical responses to angiotensin were suppressed by indapamide. Responses to noradrenaline were only diminished after pre-incubation with indapamide.

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