ELEVATED SOLUBLE INTERLEUKIN-2 RECEPTOR IN CHILDHOOD HEMOPHAGOCYTIC HISTIOCYTIC SYNDROMES

1 June 1989

journal article
research article

Vol. 73 (8) , 2128-2132

Abstract

The serum of children with untreated hemophagocytic syndromes contains elevated levels (23,600 to 75,200 U/mL) of soluble interleukin-2 receptor (SIL2R) that returns toward normal with clinical improvement. These levels are in excess of levels previously reported for benign conditions. They are as high as levels reported for HTLV-1-associated adult T-cell leukemia (HATL) and hairy cell leukemia (HCL) in adults and some children with poor-prognosis non-T, non-B, acute lymphoblastic leukemia (ALL). Serum SIL-2R is a marker of disease activity that has the potential to identify infants at risk for the inherited form of the disease before the disease is clinically expressed.

This publication has 3 references indexed in Scilit:

The Human Interleukin-2 Receptor: Normal and Abnormal Expression in T Cells and in Leukemias Induced by the Human T-Lymphotropic Retroviruses
Annals of Internal Medicine, 1986
Bacteria-associated hemophagocytic syndrome
Cancer, 1984
METHODS IN LABORATORY INVESTIGATION - APPLICATION OF THE INDIRECT ENZYME-LINKED IMMUNOSORBENT-ASSAY MICROTEST TO THE DETECTION AND SURVEILLANCE OF HUMAN T-CELL LEUKEMIA-LYMPHOMA VIRUS
1983