Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging
- 16 December 2007
- journal article
- research article
- Published by Springer Nature in Nature Methods
- Vol. 5 (1) , 57-59
- https://doi.org/10.1038/nmeth1147
Abstract
We have developed a method for integrating three dimensional–volume reconstructions of spatially resolved matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) ion images of whole mouse heads with high-resolution images from other modalities in an animal-specific manner. This approach enabled us to analyze proteomic profiles from MALDI IMS data with corresponding in vivo data provided by magnetic resonance imaging.Keywords
This publication has 10 references indexed in Scilit:
- Imaging mass spectrometry of proteins and peptides: 3D volume reconstructionNature Methods, 2008
- Direct Molecular Analysis of Whole-Body Animal Tissue Sections by Imaging MALDI Mass SpectrometryAnalytical Chemistry, 2006
- Proteomic-Based Prognosis of Brain Tumor Patients Using Direct-Tissue Matrix-Assisted Laser Desorption Ionization Mass SpectrometryCancer Research, 2005
- Three-dimensional visualization of protein expression in mouse brain structures using imaging mass spectrometryJournal of the American Society for Mass Spectrometry, 2005
- Early Changes in Protein Expression Detected by Mass Spectrometry Predict Tumor Response to Molecular TherapeuticsCancer Research, 2004
- Proteomics in Diagnostic PathologyThe American Journal of Pathology, 2004
- Assessing Protein Patterns in Disease Using Imaging Mass SpectrometryJournal of Proteome Research, 2004
- Direct analysis of drug candidates in tissue by matrix‐assisted laser desorption/ionization mass spectrometryJournal of Mass Spectrometry, 2003
- Imaging mass spectrometry: A new technology for the analysis of protein expression in mammalian tissuesNature Medicine, 2001
- An overlap invariant entropy measure of 3D medical image alignmentPattern Recognition, 1999