Growth Hormone Secretion in Children and Adolescents at High Risk for Major Depressive Disorder

Abstract
DECREASED GROWTH hormone (GH) secretion in response to pharmacologic stimulation with various substances has been reported in children and adolescents with major depressive disorder (MDD).1,2 Similarly, decreased GH secretion after stimulation has been reported in most studies of adults with MDD.3,4 Overall, the results of these studies are consistent in suggesting that GH secretion is decreased after pharmacologic stimulation among depressed subjects across the age span. In contrast, studies1,3-9 evaluating the 24-hour baseline or nocturnal secretion of GH in acutely depressed children, adolescents, and adults have yielded inconsistent results.

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