Interactions between heparan sulfate and proteins: the concept of specificity
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Open Access
- 31 July 2006
- journal article
- review article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 174 (3) , 323-327
- https://doi.org/10.1083/jcb.200604035
Abstract
Proteoglycan (PG) coreceptors carry heparan sulfate (HS) chains that mediate interactions with growth factors, morphogens, and receptors. Thus, PGs modulate fundamental processes such as cell survival, division, adhesion, migration, and differentiation. This review summarizes recent biochemical and genetic information that sheds new light on the nature of HS–protein binding. Unexpectedly, many interactions appear to depend more on the overall organization of HS domains than on their fine structure.Keywords
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